Clinical Research & Biomarkers
DCE-MRI AIF Calibration: Anatomy of a Failed Endpoint
Nine imaging centers analyzed the same prostate DCE-MRI datasets and produced substantially different pharmacokinetic results…
Clinical Research & Biomarkers
Scanner Upgrades and Biomarker Drift in Multicenter MRI
A longitudinal MRI trial can look statistically reassuring and still be measuring two different instruments.
Clinical Research & Biomarkers
QSM algorithm selection for longitudinal iron tracking
A longitudinal QSM study can fail without producing an obviously bad image. The susceptibility maps may look clean, the…
Clinical Research & Biomarkers
Feature Tracking or Tagging for Cardiac Strain MRI
Cardiac MRI strain analysis is constrained by how the myocardium is encoded before reconstruction. Myocardial tagging writes a…
News
Integrating Neurofilament Light Chain Biomarkers into Clinical MRI Workflows
Medscape has published a piece on neurofilament light chain (NfL) as a biomarker for neurologic disease, joining a tight cluster…
Clinical Research & Biomarkers
Bolus Arrival Time in ASL: How Perfusion Errors Happen
Arterial spin labeling can quantify cerebral blood flow without an injected contrast agent, but the number reported by the…
Clinical Research & Biomarkers
Ktrans in DCE-MRI: How Pharmacokinetic Modeling Works
A dynamic contrast-enhanced MRI examination can produce a series of images in which a tumor, organ, or lesion gradually changes…
Clinical Research & Biomarkers
Radiomics or deep learning for MRI trial biomarkers
An MRI biomarker is not validated because a model separates two labels. It is validated when the measured signal survives…
Clinical Research & Biomarkers
MRI biomarker drift: calibration steps for multi-center trials
A treatment effect can appear to weaken over time even when the underlying biology has not changed. In a multi-center MRI trial…
Clinical Research & Biomarkers
QSM or R2* mapping for clinical trial iron quantification?
R2* mapping and quantitative susceptibility mapping both begin with the same acquisition family: multi-echo gradient-echo MRI…
Clinical Research & Biomarkers
ASL MRI transit delay: pipeline adjustments for accuracy
Arterial spin labeling can quantify cerebral blood flow without an injected contrast agent, but the number that emerges from an…
Clinical Research & Biomarkers
Cardiac T1 mapping: can we compare metrics across vendors?
Two 3T scanners. The same field strength. Native T1 values that diverge by more than 60 milliseconds between sites: one machine…
Clinical Research & Biomarkers
DCE-MRI Ktrans validation for oncology trials
A change in tumor enhancement can look persuasive on a color-coded DCE-MRI map and still be too small, too unstable, or too…
Clinical Research & Biomarkers
MRI harmonization after scanner upgrades
There is a particular kind of disappointment that arrives, quietly, when a longitudinal neuroimaging study is interrupted…
Clinical Research & Biomarkers
QSM biomarker drift in a multi-center trial
A QSM biomarker can look impressively stable in a phantom and still become annoyingly slippery once it enters a real multi-center…